You will be given antibiotic tablets and painkillers to take for seven days after the procedure. You should continue with the alpha-blockers for another 10 days. You may experience some perineal pain or discomfort after the procedure: paracetamol or other simple painkillers should be adequate. You should avoid any medication containing aspirin for 24 hours as it causes blood thinning and will therefore increase the risk of bleeding.
You can expect to see some blood in your urine for 1 - 2 days following the biopsies. You may notice some blood in your semen for up to 3 months. If the bleeding becomes excessive, prolonged or if you start to pass blood clots then you should seek medical attention.
Occasionally swelling may occur in the prostate gland as an inflammatory response to the biopsies being taken. This can cause difficulty in passing urine and may very occasionally cause the ability to pass urine to stop completely. This is known as urinary retention and you would then need a catheter inserted to drain your bladder for a few days. You will not be allowed to go home until you have passed urine.
There is a <0.5% risk of developing sepsis (a very bad infection) following prostate biopsy. The antibiotics you will be given should help prevent this. If you develop flu-like symptoms within 24 hours of the biopsies being taken (fever, cold shivers, general aching) you should seek medical assistance immediately. You should drink plenty of fluids.
You can usually return to work the day after you have been discharged from hospital, if you feel ready to do so. It may be difficult sitting down for prolonged periods of time for the first 2-3 days.
You need to check with your insurance company about your cover following anaesthetic. You also need to feel comfortable doing an emergency stop. If you are taking any medication, check with the pharmacist whether it is safe to drive while taking them.